Converting unixhierarchysep from "." to "/": experiences?

[Jason Fesler]

> in a mailbox name.  If a server decided to use 'a' as the separator
> character, then the same would apply.  FWIW, you can tell Cyrus to use
> '/' as the separator by enabling the unixhierarchysep option in imapd.conf.

Has anyone reported any client issues by changing this setting?
SquirrelMail I can fudge the configs on easily; pine users, I know I can't
change (and I know their configs are typically hard set).  What about the
various GUIs?  Anyone have experience with converting from "." to "/"?